A disease of the brain in which cancer cells (malignant) arise in the brain tissue. Cancer cells grow to form a mass of cancer tissue (tumor) that interferes with brain functions such as muscle control, sensation, memory, and other normal body functions.
An abnormal growth of tissue in the brain. Unlike other tumors, brain tumors spread by local extension and rarely metastasize (spread) outside the brain.
Research studies done to determine whether new drugs, treatments, or vaccines are safe and effective. They are conducted in three phases:
- Phase I
In this phase, small groups of people are treated with a certain dose of a new agent that has been extensively studied in the laboratory. During the trial, the dose is increased group by group to find the highest dose that does not cause harmful side effects. Usually there is no control treatment for comparison. This process determines a safe, appropriate dose for use in Phase II.
- Phase II
This phase provides continued safety testing of a new agent, along with an evaluation of how well it works against a specific type of cancer. The new agent is given to groups of people and is usually compared with a standard treatment.
- Phase III
This phase answers research questions across the disease continuum and includes large numbers of participants so that the differences in effectiveness of the new agent can be evaluated. If the results of this phase merit further use of the new agent, the pharmaceutical company will usually submit a New Drug Application to the FDA.
The determination of the nature of a disease or ailment. A clinical diagnosis is based on the medical history and physical examination of the patient.
Cells that provide structure to the central nervous system and insulate and protect neurons (cells that transmit electrical impulses that allow seeing/hearing/smelling/tasting).
The term used to refer to the most prevalent primary brain tumors. Gliomas arise from glial tissue, which supports and nourishes cells that send messages from the brain to other parts of the body.
Also known as glioblastoma multiforme, this is the most common and aggressive malignant primary brain tumor in humans, involving glial cells and accounting for 52 percent of all functional tissue brain tumor cases and 20 percent of all intracranial tumors.
GBM is an abbreviation for glioblastoma multiforme.
Innovative advances arising from the Human Genome Project, applying them to the development of diagnostics, prognostics and therapies for cancer, neurological disorders, diabetes and other complex diseases