TGen Receives Approval for Patient Enrollment in Brain Cancer Clinical Trial

Catherine Ivy and Dr. David Craig

 

Glioblastoma (GBM) Pilot Trial funded by Ivy Foundation

In 2012, The Ben & Catherine Ivy Foundation awarded $10 million in grants for two groundbreaking brain cancer research projects at the Translational Genomics Research Institute (TGen). One of those projects has officially received the final regulatory approval from University of California, San Francisco, which means patient enrollment for the trial can begin.

 

In the $5-million-project, “Genomics Enabled Medicine in Glioblastoma Trial,” TGen and its clinical partners will lead first-in-patient clinical trial studies that will test promising new drugs that might extend the survival of GBM patients. This multi-part study will take place in clinics across the country and TGen laboratories.

 

“GBM is one of the top three fastest-killing cancers out there and it affects people of all ages,” said Catherine (Bracken) Ivy, founder and president of The Ben & Catherine Ivy Foundation. “It is critical that we fund research that will help patients live longer so we can study and treat brain cancer.”

 

The project begins with a pilot study of 15 patients, using whole genome sequencing to study their tumor samples to help physicians determine what drugs might be most beneficial.

 

To support molecularly informed clinical decisions, TGen labs also will examine genomic data from at least 536 past cases of glioblastoma, as well as tumor samples from new cases, developing tools that will produce more insight into how glioblastoma tumors grow and survive. TGen also will conduct a series of pioneering lab tests to measure cell-by-cell responses to various drugs.

 

“GBM is a disease that needs answers now, and we strongly believe those answers will be found in the genome,” said Dr. David Craig, TGen’s Deputy Director of Bioinformatics, Director of TGen’s Neurogenomics Division, and one of the projects principal investigators. “Identifying the genes that contribute to the survival of glioblastoma will provide valuable information on how to treat it, and may also lead to an improved understanding of what drives other cancers as well.”

 

To get new treatments to patients as quickly as possible, this five-year study will include a feasibility study involving up to 30 patients, followed by Phase II clinical trials with as many as 70 patients. TGen is teaming with the Ivy Early Phase Clinical Trials Consortium that includes: University of California, San Francisco; University of California, Los Angeles; the MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; University of Utah; and the Dana-Farber/Harvard Cancer Center.

 

The results of these clinical trials should not only help the patients who join them, but also provide the data needed for FDA approval and availability of new drugs that could benefit tens of thousands of brain cancer patients in the future.

 

“Working with physicians, the project will aim to understand treatment in the context of the tumor’s molecular profile. We will have the opportunity to determine when combinations of drugs might be more effective than using a single drug, quickly identify which therapies don’t work, and accelerate discovery of ones that might prove promising for future development,” said Dr. John Carpten, TGen’s Deputy Director of Basic Science, Director of TGen’s Integrated Cancer Genomics Division, and another of the project’s principal investigators.

 

In addition to helping patients as quickly as possible, the project should significantly expand Arizona’s network of brain cancer experts.

 

About The Ben & Catherine Ivy Foundation

The Ben & Catherine Ivy Foundation, based in Scottsdale, Ariz., was formed in 2005, when Ben Ivy lost his battle with glioblastoma multiforme (GBM).  Since then, the Foundation has contributed more than $50 million to research in gliomas within the United States and Canada, with the goal of better diagnostics and treatments that offer long-term survival and a high quality of life for patients with brain tumors.  The Ben & Catherine Ivy Foundation is the largest privately funded foundation of its kind in the United States.  For more information, visit http://www.ivyfoundation.org. We have regular updates via social media – please find us on:

Blog:  Ivy Foundation http://www.IvyFoundation.wordpress.com

Facebook:  Ivy Foundation  http://www.facebook.com/IvyFoundation

Twitter:  @IvyFoundation https://twitter.com/IvyFoundation

Google+:   Ivy Foundation https://plus.google.com/105982076267406579679/posts

LinkedIn:  Ivy Foundation http://linkedin.com/company/the-ben-and-catherine-ivy-foundation

YouTube:  IvyFoundationGBM http://www.youtube.com/user/IvyFoundationGBM

 

About TGen

The Translational Genomics Research Institute (TGen) is a Phoenix-based non-profit organization dedicated to conducting groundbreaking research with life changing results. Research at TGen is focused on helping patients with diseases such as cancer, neurological disorders and diabetes. TGen is on the cutting edge of translational research where investigators are able to unravel the genetic components of common and complex diseases. Working with collaborators in the scientific and medical communities, TGen believes it can make a substantial contribution to the efficiency and effectiveness of the translational process. For more information, visit: www.tgen.org.

Ivy Foundation Helps Transform Healthcare

Ivy Foundation Biomedical Innovation Fund Doubles Support for U.Va. Projects Benefiting Human Health

New commitments from the Ivy Foundation and the University of Virginia School of Medicine will double the annual Ivy Biomedical Innovation Fund’s research awards for U.Va. faculty, while advancing discoveries to better diagnose and treat disease.

The Ivy Foundation Biomedical Innovation fund supports projects that involve School of Medicine faculty members and other investigators from multiple departments, schools and specialties across the University.

Since the creation of the Ivy Biomedical Innovation Fund in 2008, the Ivy Foundation has awarded $860,000 to University research collaborations that have the potential to yield leading-edge diagnostics, technology and treatments for a wide range of human health problems.

Each year, the fund awards approximately $200,000, with individual awards averaging $50,000. Beginning in 2013, the Ivy Foundation will increase its annual contribution, which will be matched by the School of Medicine to provide awards totaling $500,000 annually.

“The scope of projects funded over the past five years has been impressive,” said Dr. Robert W. Battle, who chairs the Ivy Foundation and directs U.Va.’s Adult Congenital Heart Clinic. “This research will make a real and immediate difference for patients. It’s gratifying to see the work that has been accomplished through the Ivy Foundation’s support. I look forward to seeing the impact that these added resources will make possible.”

In 2012, a record number of U.Va. researchers and clinicians applied for funding, with 28 proposals coming from U.Va.’s College of Arts & Sciences, School of Engineering and Applied Science, School of Medicine, School of Nursingand Medical Center.

Read more here: http://bit.ly/1gQalnU

Ivy Foundation Funds Society of St. Vincent de Paul Diabetes Program

Posted: Thursday, August 15, 2013 3:45 am

http://bit.ly/1gQaibq

The Ben & Catherine Ivy Foundation (Ivy Foundation) announced its funding of the Family Wellness Program managed by the Society of St. Vincent de Paul, Phoenix.

The Ivy Foundation is the largest privately funded brain cancer research foundation in North America; Catherine Ivy is the founder and president of the Ivy Foundation.

The Family Wellness Program is a culturally responsive diabetes intervention program that provides education, lifestyle improvement skills, medical, and counseling services to adults, children, and their families who have been diagnosed with diabetes and pre-diabetes and its associated comorbidities (two or more medical conditions present simultaneously in a patient).

The overall goal is to empower these families with the knowledge, tools and skills to make health a priority throughout their lives.

Ivy Foundation Funds Diabetes Program

http://frontdoorsnews.com

Ivy Foundation Funds Diabetes Intervention

Posted By  on July 22, 2013

Catherine Ivy and St Vincent de PaulThe Ben & Catherine Ivy Foundation (Ivy Foundation) announced its funding of the Family Wellness Program managed by the Society of St. Vincent de Paul, Phoenix. The Ivy Foundation is the largest privately funded brain cancer research foundation in North America; Catherine Ivy is the founder and president of the Ivy Foundation.

The Family Wellness Program is a culturally responsive diabetes intervention program which provides education, lifestyle improvement skills, medical, and counseling services to adults, children, and their families who have been diagnosed with diabetes and pre-diabetes and its associated comorbidities (two or more medical conditions present simultaneously in a patient). The overall goal is to empower these families with the knowledge, tools and skills to make health a priority throughout their lives.

Specific program objectives include:

  • Affecting lifestyle choices in food, fitness, and self-efficacy that enhance and establish ongoing positive health behaviors;
  • Increasing knowledge and skills in recognizing, managing and improving risk factors, disease, and quality of life throughout the life span;
  • Measuring health changes through objective and subjective instruments.
  • Evaluating effectiveness of and fine-tuning the model using community- based participatory research;
  • Responding to the increasing need for intervention by developing competent professionals who can replicate the model throughout the community.

“While we typically only fund brain cancer research programs, we knew the impact of this program was so strong and the need so great in our local community that we chose to support it,” said Ivy. “We also learn from the research of other diseases and this gives us a fresh perspective.”

“There is proven success with this program. The majority of participants have demonstrated significant improvements in their health as seen in laboratory markers. Patients are healthier. They come back as alumni to attend classes in order to receive continued social support for their lifestyle changes from program staff, volunteers and fellow participants,” said Society of St. Vincent de Paul, Phoenix, Executive Director Steve Zabilski. “We are grateful to the Ivy Foundation for their support of this high-impact program.”

http://frontdoorsnews.com/2013/07/ivy-foundation-funds-diabetes-intervention/

Ivy Foundation in Oncology Times

The Ben & Catherine Ivy Foundation has awarded the following individuals grants and funding for brain cancer research in 2012:

  • Greg D. Foltz, MD, Director of the Ben & Catherine Ivy Center for Advanced Brain Tumor Treatment at the Swedish Medical Center, $2.5 million over three years;
  • John Carpten, PhD, and David Craig, PhD, both of the Translational Genomics Research Institute for a collaborative effort with researchers at the University of California, San Francisco, UCLA, Memorial Sloan-Kettering Cancer Center, Massachusetts General Hospital, Dana Farber/Harvard Cancer Center, MD Anderson Cancer Center, and University of Utah, $5 million over five years; and
  • Brandy Wells, Manager of Science Education and Outreach at the Translational Genomics Research Institute, has received $45,000 annually for the Ivy Neurological Sciences Internship Program.

For more information: http://journals.lww.com/oncology-times/Fulltext/2013/06250/SHOP_TALK__Appointments,_Promotions,_Honors,.18.aspx

Check Out Ivy Foundation in AZ Business Magazine!

IVY FOUNDATION GRANTS OVER $9M FOR BRAIN CANCER RESEARCH

Posted on May 20, 2013 by News Release

prevention trial - brain scan images

The Ben & Catherine Ivy Foundation (Ivy Foundation) announced its 2012 grant recipients, which total more than $9 million in funding for brain cancer research. The Ivy Foundation is the largest privately funded brain cancer research foundation in North America. Catherine Ivy is the founder and president of the Ivy Foundation, which has a research funding focus on glioblastoma multiforme (GBM), the most common and deadliest of malignant primary brain tumors in adults.

The Ivy Foundation awarded the following grants and/or provided funding in 2012:

· $2,500,000 over three years:  Principal Investigator, Greg D. Foltz, M.D., Director, The Ben & Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Medical Center
· $5,000,000 over five years:  Principal Investigators, John Carpten, Ph.D. and David Craig, Ph.D., Translational Genomics Research Institute (TGen) – a collaborative effort with University of California, San Francisco; University of California, Los Angeles; Memorial Sloan-Kettering Cancer Center; Massachusetts General Hospital; Dana Farber/Harvard Cancer Center; MD Anderson; and University of Utah
· $45,000 annually: Principal Investigator, Brandy Wells, Translational Genomics Research Institute (TGen), for the Ivy Neurological Sciences Internship program
· Over $2 million paid out in 2012 for previously committed multi-year brain cancer research grants

“We are encouraged and remain strongly committed to moving the progress forward for patients diagnosed with brain cancer,” said Ivy. “The 2012 Ivy Foundation grant recipients are important strategic partners in our objective to double the life expectancy of people diagnosed with GBM within the next seven years.”

http://aznow.biz/health-care/ivy-foundation-grants-9m-brain-cancer-research

The Ivy Foundation in Philanthropy Journal

05.23.13: U.S. News Bits

May 23, 2013

News about grants, gifts

The Ben & Catherine Ivy Foundation (Ivy Foundation) announced its 2012 grant recipients, which will receive more than $9 million in funding for brain cancer research: $2.5 million for three years, The Ben & Catherine Ivy Center for Advanced Brain Tumor Treatment; $5 million for five years; Translational Genomics Research Institute; $45,000 annually, Translational Genomics Research Institute for the Ivy Neurological Sciences Internship program; and more than $2 million paid out in 2012 for previously committed multi-year brain cancer research grants.

The Mutual of Omaha Foundation has approved $5.42 million in grants to eight nonprofit organizations, including a $5 million commitment to the University of Nebraska Foundation in support of The Fred and Pamela Buffett Cancer Center. This list of recipients along with descriptions of each project can be found on the foundation’s website.

The Partnership for Los Angeles Schools raised close to $1.4 million from its inaugural gala dinner and benefit. Net proceeds from the event will be used to support the partnership’s key school turnaround strategies, which include investing in strong school leaders, quality teachers, targeted student supports and family and community engagement.

Learning Leaders, a New York City nonprofit dedicated to engaging families and communities to support student success, raised more than $265,000 at its third annual education forum and spring luncheon. The proceeds from the forum will go towards Learning Leaders’ family engagement and volunteer programs in the city’s public schools.

West Memphis-based CITGO Marketer Flash Oil and CITGO Petroleum Corporation teamed up with the Muscular Dystrophy Association (MDA) for the Muscle Team Madness event in Little Rock, Ark. Raising more than $16,000 to support the local MDA summer programs, these funds will cover the cost for 20 children to attend Camp Aldersgate in Little Rock.

The Independence Blue Cross (IBC) Foundation awarded a $10,000 grant to theLinda Creed Epstein Breast Cancer Foundation in Philadelphia to provide uninsured women with free breast cancer screenings, diagnostic testing services and breast health education. This spring, approximately 140 uninsured women will benefit from free screening services at up to five area hospitals because of the grant.

Today, Ford Foundation President Luis Ubiñas will join South African Parliament member Wilmot G. James and other guests from around the world to celebrate the Ford Foundation International Fellowships Program (IFP) -recipient of the single-largest grant in the foundation’s history. More than 4,300 fellows from Africa, Asia, Latin America, the Middle East and Russia have studied at universities worldwide thanks to support from Ford IFP, a groundbreaking, graduate-level fellowship program that emphasizes access and equity in higher education for talented social justice leaders from marginalized communities worldwide.

The University of Houston (UH) received a legacy gift from The Stanford and Joan Alexander Foundation to create The Stanford Alexander Center for Excellence in Real Estate in UH’s C.T. Bauer College of Business.

News about people, groups

The board of directors of Chittenden County’s Women Helping Battered Women, a Burlington, Vt., nonprofit which aids victims of domestic violence and works to prevent violence against spouses and children, announced that Executive Director Jane Van Buren will step down after completing three years in the role. The board has initiated a search to fill a newly established role, director of development and communications.

More than 250 philanthropists, grantmakers and community leaders gathered Connecticut Council for Philanthropy’s annual Connecticut Philanthropy Summit to honor three philanthropic leaders. Andy Eder was named the recipient of the 2013 John H. Filer Award for his leadership in promoting private action for the public good. David Nee, executive director of the Hamden-based William Caspar Graustein Memorial Fund, was named the recipient of the 2013 Martha S. Newman Award. Nancy Roberts was honored by the establishment of a new award, “The Nancy Roberts Award for Innovation in Philanthropy.” The award will be given to a foundation or other funder each year, beginning at the 2014 Philanthropy Summit.

National Braille Press announced that Jay Hooley, chairman, president and CEO of State Street Bank, will receive the Hands On! Award at its 2013 “A Million Laughs for Literacy” annual gala on Nov. 1 at the Westin Boston Waterfront Hotel. The event brings together business and community leaders who are dedicated to the organization’s mission to promote literacy for blind children.

The League of American Orchestras board of directors has elected Angelo M. Fatta as chair elect. Fatta will assume this position in June and will hold it until June 2014, when his election to succeed Lowell J. Noteboom as chair will take place.

The United States Tennis Association (USTA) announced that Dan Faber has been named executive director of USTA Serves, the national charitable foundation of the USTA. In this role, Faber will be dedicated to increasing the outreach of the 19-year-old foundation and continuing its mission of changing lives through tennis and education.

PTel Mobile, a leader in no-contract wireless, launched GIV Mobile, the first consumer conscious no-contract mobile service that is dedicated to donating eight percent of monthly “unlimited everything” plans to a nonprofit charity of the customer’s choice such as the Alzheimer’s Association, St. Jude Children’s Research Hospital, American Red Cross, United Way Worldwide, Scholarship America, and more. For information about GIV Mobile wireless service, visit www.givmobile.com.

M&M’S has partnered with Habitat for Humanity to help M’Prove America, giving back to communities around the county. The brand is rallying fans to donate 1.5 million minutes of volunteer time at Habitat for Humanity job sites throughout the nation at www.mproveamerica.com. M&M’S plans to donate $500,000 to fund the construction of Habitat for Humanity homes around the U.S., but fans can also support the “America is Better With M” program by purchasing special merchandise at M&M’S World stores in Orlando, Las Vegas, Henderson, Nev., and New York.

News about opportunities, initiatives

Through June 14, NASCAR fans can submit their nominations for the 2013 Betty Jane France Humanitarian Award (BJFHA) by logging onto NASCAR.com/foundation. The BJFHA is presented annually to one passionate NASCAR fan that has made a profound impact on children in his or her local community. The NASCAR Foundation board of directors will determine four finalists who then move on to the online fan voting phase. The finalist who amasses the most votes during this period will be declared the national winner, and will be announced live on stage during the 2013 NASCAR Sprint Cup Series Awards Ceremony in Las Vegas and will be awarded with a $100,000 donation to their children’s charity of choice while three remaining finalists will receive $25,000 donations to their children’s charities of choice.

The International Coach Federation (ICF) has opened nominations for the 2013 ICF International Prism Award. The award honors organizations that have achieved a standard of excellence in the implementation of coaching programs for culture change, leadership development, productivity and performance improvement. Coaches and organizations interested in nominating candidates for the 2013 ICF International Prism Award can find more information at Coachfederation.org/prism. The nomination period closes at 5 p.m. (EST) July 31.

A new, free online resource for staff and board members of charitable nonprofits, as well as the accountants that they work with, was unveiled by the National Council of Nonprofits (Council of Nonprofits). The Nonprofit Audit Guide, created with support from the First Nonprofit Foundation, is the first comprehensive, web-based resource for nonprofits that explains the complex requirements and process for a financial audit. The Nonprofit Audit Guide can be found online and will be updated regularly with new resources.

http://www.philanthropyjournal.org/news/top-stories/052313-us-news-bits

Ben and Catherine Ivy Foundation Grants Over $9 Million for Brain Cancer Research

Largest privately funded brain cancer research foundation provides 2012 grant recap

Scottsdale, Ariz. (May 20, 2013) – The Ben & Catherine Ivy Foundation (Ivy Foundation) announced its 2012 grant recipients, which total more than $9 million in funding for brain cancer research. The Ivy Foundation is the largest privately funded brain cancer research foundation in North America. Catherine Ivy is the founder and president of the Ivy Foundation, which has a research funding focus on glioblastoma multiforme (GBM), the most common and deadliest of malignant primary brain tumors in adults.

The Ivy Foundation awarded the following grants and/or provided funding in 2012:

  • $2,500,000 over three years:  Principal Investigator, Greg D. Foltz, M.D., Director, The Ben & Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Medical Center
  • $5,000,000 over five years:  Principal Investigators, John Carpten, Ph.D. and David Craig, Ph.D., Translational Genomics Research Institute (TGen) – a collaborative effort with University of California, San Francisco; University of California, Los Angeles; Memorial Sloan-Kettering Cancer Center; Massachusetts General Hospital; Dana Farber/Harvard Cancer Center; MD Anderson; and University of Utah
  • $45,000 annually: Principal Investigator, Brandy Wells, Translational Genomics Research Institute (TGen), for the Ivy Neurological Sciences Internship program
  • Over $2 million paid out in 2012 for previously committed multi-year brain cancer research grants

“We are encouraged and remain strongly committed to moving the progress forward for patients diagnosed with brain cancer,” said Ivy. “The 2012 Ivy Foundation grant recipients are important strategic partners in our objective to double the life expectancy of people diagnosed with GBM within the next seven years.”